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promyelocytic (M3) acute leukaemia; a variety of sufferers Categorical an strange morphologic spectrum intermediate concerning M2 and M3 AML.
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significant rate of typical or dystrophic promyelocytes in peripheralblood and in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction constructive; immunocytochemical detection by having an anti-PLZF reveals adistinct punctate nuclear distribution from the protein, suggesting itscompartmentalization while in the nucleus.
Swift detection of prognostically significant fusion transcripts in acute leukemia making use of simplified multiplex reverse transcription polymerase chain reaction.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a scenario report and review of literature.
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Profitable allogeneic bone marrow transplantation within a case of variant acute promyelocytic leukemia with ZBTB16-RARA.
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A scenario of acute promyelocytic leukaemia with unusual cytological characteristics and a ZBTB16-RARA fusion gene.
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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.
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the translocation entails a breakpoint within the zinc fingerregion of PLZF, with fusion of two zinc fingers towards the RARa B location toform a 5 PLZF - 3 RARa fusion gene; the reciprocal five RARa - 3 PLZF genefuses 7 zinc fingers for the RARa area; RARas breakpoint occurs in1- due to thealternative splicing of PLZF gene, two types of PLZF-RARa protein may be detected: